Nathan Constantine-Cooke

Selected publications

1. Gut

   Associations between demographic, clinical and dietary factors and flares in inflammatory bowel disease: The PRognostic effect of Environmental factors in Crohn’s and Colitis (PREdiCCt) prospective cohort study

   Nathan Constantine-Cooke, Beatriz Gros, Nikolas Plevris, Linda J Williams, Gareth-Rhys Jones, Janet Kyle, Nicholas A Kennedy, Victor Velasco-Pardo, Alexander Rudge, Debbie Alexander, Carl A Anderson, Maiara Freitas, Lisa M Derr, Lauranne AAP Derikx, Sian Gilchrist, Paul Henderson, Graham W Horgan, Peter Irving, Christopher A Lamb, Luke Jostins-Dean, James O Lindsay, Jonathan MacDonald, Craig Mowat, Charles Murray, Miles Parkes, Spyros I Siakavellas, Catalina A Vallejos, Daniel R Gaya, Jonathan M Rhodes, Alexandra M Johnstone, Christopher J Weir, and Charlie W Lees

   Gut 2026

   Abs Bib URL

   Background IBD is characterised by recurrent flares, but evidence on whether modifiable dietary factors influence flare risk is limited.Objective The PREdiCCt study was designed to examine demographic, clinical and dietary factors associated with disease flare among patients with IBD in self-reported remission.Design Multicentre, prospective cohort study conducted across 47 UK centres. Patients with Crohn’s disease (CD), ulcerative colitis (UC) or IBD unclassified (IBDU) in self-reported remission were prospectively followed up. The baseline diet was assessed using a validated food frequency questionnaire. The primary outcome was time to patient-reported flare (captured by monthly IBD-Control) and objective flare (clinical flare plus C-reactive protein >5 mg/L and/or faecal calprotectin (FC) >250 \textmug/g with treatment escalation). Associations were evaluated using Cox frailty models adjusted for demographic, clinical and biochemical variables, including baseline FC.Results Between November 2016 and March 2020, 2629 participants (1370 CD; 1259 UC/IBDU) were enrolled and followed up for a median of 4.1 years (IQR 3.0–5.0). Baseline FC was strongly associated with patient-reported flares (FC >=250 \textmug/g: adjusted HR (aHR) 2.22; FC 50–250 \textmug/g: aHR 1.52 (reference <50 \textmug/g)) and objective flares (FC >=250 \textmug/g: aHR 3.25; FC 50–250 \textmug/g: aHR 1.98). In UC, higher total meat intake was associated with increased risk of objective flares (highest versus lowest quartile: aHR 1.95, 95% CI 1.07 to 3.56). No consistent associations were observed for ultraprocessed foods, fibre or polyunsaturated fatty acids and flare.Conclusion Higher habitual meat intake was associated with increased risk of objective flare in UC, suggesting diet may contribute to flare susceptibility in specific patient groups.Trial registration number NCT03282903.Data are available upon reasonable request. Participant-level data are not currently available to external researchers. Data are expected to be available for external researchers under a responsible data sharing model following the publishing of planned manuscripts.

   @article{Constantine-Cookegutjnl-2025-337846,
     selected = {true},
     abbr = {Gut},
     bibtex_show = {true},
     author = {Constantine-Cooke, Nathan and Gros, Beatriz and Plevris, Nikolas and Williams, Linda J and Jones, Gareth-Rhys and Kyle, Janet and Kennedy, Nicholas A and Velasco-Pardo, Victor and Rudge, Alexander and Alexander, Debbie and Anderson, Carl A and Brusco de Freitas, Maiara and Derr, Lisa M and Derikx, Lauranne AAP and Gilchrist, Sian and Henderson, Paul and Horgan, Graham W and Irving, Peter and Lamb, Christopher A and Jostins-Dean, Luke and Lindsay, James O and MacDonald, Jonathan and Mowat, Craig and Murray, Charles and Parkes, Miles and Siakavellas, Spyros I and Vallejos, Catalina A and Gaya, Daniel R and Rhodes, Jonathan M and Johnstone, Alexandra M and Weir, Christopher J and Lees, Charlie W},
     editor = {},
     title = {Associations between demographic, clinical and dietary factors and flares in inflammatory bowel disease: {The} {PRognostic} effect of {Environmental} factors in {Crohn{\textquoteright}s} and {Colitis} ({PREdiCCt}) prospective cohort study},
     elocation-id = {gutjnl-2025-337846},
     year = {2026},
     doi = {10.1136/gutjnl-2025-337846},
     publisher = {BMJ Publishing Group},
     issn = {0017-5749},
     url = {https://gut.bmj.com/content/early/2026/01/19/gutjnl-2025-337846},
     eprint = {https://gut.bmj.com/content/early/2026/01/19/gutjnl-2025-337846.full.pdf},
     journal = {Gut}
   }

2. CGH

   Large-scale clustering of longitudinal fecal calprotectin and C-reactive protein profiles in inflammatory bowel disease

   Nathan Constantine-Cooke, Marie Vibeke Vestergaard, Nikolas Plevris, Karla Monterrubio-Gómez, Clara Ramos-Belinchón, Solomon Ong, Alexander T. Elford, Beatriz Gros, Aleksejs Sazonovs, Gareth-Rhys Jones, Tine Jess, Catalina A. Vallejos, and Charlie W. Lees

   Clinical Gastroenterology and Hepatology Dec 2025

   Bib URL

   @article{Constantine_Cooke_2025,
     selected = {true},
     abbr = {CGH},
     bibtex_show = {true},
     title = {Large-scale clustering of longitudinal fecal calprotectin and {C-reactive} protein profiles in inflammatory bowel disease},
     issn = {1542-3565},
     url = {http://dx.doi.org/10.1016/j.cgh.2025.12.022},
     doi = {10.1016/j.cgh.2025.12.022},
     journal = {Clinical Gastroenterology and Hepatology},
     publisher = {Elsevier BV},
     author = {Constantine-Cooke, Nathan and Vestergaard, Marie Vibeke and Plevris, Nikolas and Monterrubio-Gómez, Karla and Ramos-Belinchón, Clara and Ong, Solomon and Elford, Alexander T. and Gros, Beatriz and Sazonovs, Aleksejs and Jones, Gareth-Rhys and Jess, Tine and Vallejos, Catalina A. and Lees, Charlie W.},
     year = {2025},
     month = dec
   }

3. JCC

   Tofacitinib versus vedolizumab among bio-naïve patients with ulcerative colitis: A real-world propensity-weighted comparison

   Nathan Constantine-Cooke, Beatriz Gros, Jake Kennedy, Alexander T Elford, Claire O’Hare, Colin Noble, Gareth-Rhys Jones, Ian D Arnott, Charlie W Lees, and Nikolas Plevris

   Journal of Crohn’s and Colitis Dec 2024

   Bib URL

   @article{Gros_2024,
     abbr = {JCC},
     bibtex_show = {false},
     title = {Tofacitinib versus vedolizumab among bio-naïve patients with ulcerative colitis: A real-world propensity-weighted comparison},
     issn = {1876-4479},
     url = {http://dx.doi.org/10.1093/ecco-jcc/jjae188},
     doi = {10.1093/ecco-jcc/jjae188},
     journal = {Journal of Crohn's and Colitis},
     publisher = {Oxford University Press (OUP)},
     author = {Constantine-Cooke, Nathan and Gros, Beatriz and Kennedy, Jake and Elford, Alexander T and O'Hare, Claire and Noble, Colin and Jones, Gareth-Rhys and Arnott, Ian D and Lees, Charlie W and Plevris, Nikolas},
     year = {2024},
     month = dec,
     selected = {true}
   }