About
Introduction
This website presents comprehensive statistical analyses from the PREdiCCt study (NCT03282903), a UK-wide prospective cohort study investigating inflammatory bowel disease (IBD) in adult patients. The study was designed to identify predictive biomarkers and clinical factors associated with disease flares in people living with Crohn’s disease (CD) and ulcerative colitis (UC).
The PREdiCCt study recruited participants in clinical remission across multiple UK centers, collecting detailed baseline characteristics including demographics, disease history, biochemistry markers, dietary patterns, and psychosocial factors. Participants were followed prospectively to identify disease flares, enabling comprehensive survival analyses to understand factors influencing time-to-flare outcomes.
This analysis website provides two main categories of statistical reports:
Baseline Analyses: Comprehensive descriptive statistics of participant recruitment, demographics, IBD characteristics, biochemistry profiles, dietary patterns, and summary tables comparing key variables across disease types and faecal calprotecin categories.
Survival Analyses: Time-to-flare analyses examining both patient-reported and objective flare definitions, with controlled analyses investigating associations between baseline factors (particularly faecal calprotectin levels and dietary patterns) and disease outcomes.
All analyses are conducted using reproducible research practices with R and Quarto, ensuring transparency and scientific rigor. The reports include both exploratory data visualizations and formal statistical modeling, with results presented in HTML format.
This work uses data provided by patients and collected by the NHS as part of their care and support. We are grateful to participants and their IBD care teams for their support.
Using this website
The code button at the top of each page can be used to show all code blocks instead of clicking on the code buttons for each individual block of code. Moving the mouse pointer over any citations in a report will produce a pop up box with reference details. Clicking on the citation will link to the bibliography at the bottom of the page.
Software versions
All analyses have been generated using R version 4.4.0. Please see the Session Information sections at the bottom of each report to see the R packages used for that particular analysis and the respective package versions.
Acknowledgements
This work uses data provided by participants and the NHS. We are grateful to the study participants and their IBD care teams for their support.
The PREdiCCt study was funded by Cure Crohn’s Colitis, Crohns & Colitis In Childhood, the Chief Scientist Office, and UKRI.
